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Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats
Joint Authors
Monteiro, Marta Chagas
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Bittencourt, Leonardo Oliveira
Pamplona-Santos, Dinair
Lamarão-Vieira, Kátia
Nascimento, Priscila C.
Corrêa, Márcio G.
dos Santos, Savio M.
Cartágenes, Sabrina C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-18
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Ethanol (EtOH) binge drinking is characterized by high EtOH intake during few hours followed by withdrawal.
Protection strategies against the damages generated by this binge are poorly explored.
Thus, this study is aimed at investigating the protective role of treadmill physical exercise (PE) on the damage caused after repeated cycles of binge-like EtOH exposure in the oxidative biochemistry, morphology, and cerebellar function of rats from adolescence to adulthood.
For this, animals were divided into four groups: control group (sedentary animals with doses of distilled water), exercised group (exercised animals with doses of distilled water), EtOH group (sedentary animals with doses of 3 g/kg/day of EtOH, 20% w/v), and exercised+EtOH group (exercised animals with previous mentioned doses of EtOH).
The PE occurred on a running treadmill for 5 days a week for 4 weeks, and all doses of EtOH were administered through intragastric gavage in four repeated cycles of EtOH in a binge-like manner.
After the EtOH protocol and PE, animals were submitted to open field and beam walking tests.
In sequence, the cerebellums were collected for the biochemical and morphological analyses.
Biochemical changes were analyzed by measurement of Trolox equivalent antioxidant capacity (TEAC), reduced glutathione content measurements (GSH), and measurement of nitrite and lipid peroxidation (LPO).
In morphological analyses, Purkinje cell density evaluation and immunohistochemistry evaluation were measured by antimyelin basic protein (MBP) and antisynaptophysin (SYP).
The present findings demonstrate that the binge drinking protocol induced oxidative biochemistry misbalance, from the decrease of TEAC levels and higher LPO related to tissue damage and motor impairment.
In addition, we have shown for the first time that treadmill physical exercise reduced tissue and functional alterations displayed by EtOH exposure.
American Psychological Association (APA)
Lamarão-Vieira, Kátia& Pamplona-Santos, Dinair& Nascimento, Priscila C.& Corrêa, Márcio G.& Bittencourt, Leonardo Oliveira& dos Santos, Savio M.…[et al.]. 2019. Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204864
Modern Language Association (MLA)
Lamarão-Vieira, Kátia…[et al.]. Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1204864
American Medical Association (AMA)
Lamarão-Vieira, Kátia& Pamplona-Santos, Dinair& Nascimento, Priscila C.& Corrêa, Márcio G.& Bittencourt, Leonardo Oliveira& dos Santos, Savio M.…[et al.]. Physical Exercise Attenuates Oxidative Stress and Morphofunctional Cerebellar Damages Induced by the Ethanol Binge Drinking Paradigm from Adolescence to Adulthood in Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1204864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204864