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Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome
Joint Authors
Kor, Chew-Teng
Su, Wei-Wen
Wu, Shun-Sheng
Chen, Ting-Yu
Liu, Ko-Hung
Shih, Kai-Lun
Wu, Hung-Ming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases.
This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT).
We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n=21; one, n=19; two, n=27; three, n=26; four, n=25; five, n=16).
Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma.
We found that carotid IMT positively correlated with both MDA and uric acid levels.
Multivariate analysis revealed that both MDA (p<0.05) and uric acid (p<0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were ≥1 or ≥2.
However, only uric acid (p<0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome.
Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively.
These were better than the predication accuracies from MDA (r2=0.075) and uric acid (r2=0.148) individually.
These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.
American Psychological Association (APA)
Wu, Shun-Sheng& Kor, Chew-Teng& Chen, Ting-Yu& Liu, Ko-Hung& Shih, Kai-Lun& Su, Wei-Wen…[et al.]. 2019. Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204888
Modern Language Association (MLA)
Wu, Shun-Sheng…[et al.]. Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1204888
American Medical Association (AMA)
Wu, Shun-Sheng& Kor, Chew-Teng& Chen, Ting-Yu& Liu, Ko-Hung& Shih, Kai-Lun& Su, Wei-Wen…[et al.]. Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1204888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204888