O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Since both O-GlcNAcylation and autophagy sense intracellular nutrient level, the alteration of those two pathways plays substantial roles in the progression of heart failure.
Hence, determining the relationship between O-GlcNAcylation and autophagy is imperative to understand, prevent, and treat heart failure.
However, the mechanism on how O-GlcNAcylation regulates autophagy in the heart is poorly investigated.
In this study, we demonstrated that O-GlcNAcylation is required for autophagy in cardiomyocytes by utilizing an O-linked β-N-acetylglucosamine transferase (OGT) cardiomyocyte-specific knockout mouse model for the first time.
We also identified that OGT might regulate the initiation of autophagy in cardiomyocytes through promoting the activity of ULK1 by O-GlcNAcylation.
In conclusion, our findings provide new insights into the molecular mechanisms underlying heart dysfunction and benefit the development of treatments for heart failure.
American Psychological Association (APA)
Yu, Houzhi& Wen, Li& Mu, Y.. 2020. O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204890
Modern Language Association (MLA)
Yu, Houzhi…[et al.]. O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204890
American Medical Association (AMA)
Yu, Houzhi& Wen, Li& Mu, Y.. O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204890