Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy
Joint Authors
Zhang, Zhang-Jin
Zheng, Yu
Zhou, Xi-Dan
Sharma, Rakesh
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-25
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Our previous study has demonstrated the effects of aqueous extract of lily bulb in alleviating menopause-related psychiatric symptoms in ovariectomized (OVX) mice.
This study sought to further investigate the psychotropic effects of total polysaccharides of lily bulb (TPLB) against anxiety, depression, and cognitive deterioration and the underlying mechanisms in OVX mice using behavioral, neurochemical, molecular, and proteomic approaches in comparison with estrogen therapy.
While TPLB and estradiol showed similar effects in reducing OVX-induced anxiety, depression, and cognitive impairment, the psychotropic effects of TPLB were more closely associated with the predominant activation of estrogen receptors (ERs) and regulation of brain regional neurotransmitters and neurotrophins with minor effects on the uterus.
Estradiol had similar potencies in binding affinity at ERα and ERβ, which caused widespread genetic and epigenetic effects.
In contrast, TPLB displayed a higher affinity at ERβ than ERα, triggering the specific Ras/Akt/ERK/CREB signaling pathway without affecting any epigenetic activity.
TPLB additionally modulated multiple proteins associated with mitochondrial oxidative stress, but estradiol did not.
These results indicate that TPLB has comparable efficacy in reducing menopause-associated neuropsychological symptoms with a better safety profile compared to estrogen therapy.
We suggest that TPLB could serve as a novel agent for menopause syndrome.
American Psychological Association (APA)
Zhou, Xi-Dan& Zheng, Yu& Sharma, Rakesh& Zhang, Zhang-Jin. 2019. Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1204893
Modern Language Association (MLA)
Zhou, Xi-Dan…[et al.]. Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-27.
https://search.emarefa.net/detail/BIM-1204893
American Medical Association (AMA)
Zhou, Xi-Dan& Zheng, Yu& Sharma, Rakesh& Zhang, Zhang-Jin. Total Polysaccharides of Lily Bulb Ameliorate Menopause-Like Behavior in Ovariectomized Mice: Multiple Mechanisms Distinct from Estrogen Therapy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1204893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204893