Oral Administration of Lactobacillus delbrueckii during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model
Joint Authors
Yang, Lingyuan
Huang, Xingguo
Li, Yinghui
Hou, Shuling
Peng, Wei
Lin, Qian
Chen, Fengming
Li, Fengna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Early colonization in the gut by probiotics influences the progressive development and maturity of antioxidant and immune system functionality in the future.
This study investigated the impact of orally administrated Lactobacillus delbrueckii (LAB) during the suckling phase on future antioxidant and immune responses of the host, using a piglet model.
One hundred neonatal piglets received saline (CON) or LAB at the amounts of 1, 2, 3, and 4 mL at 1, 3, 7, and 14 d of age, respectively.
The piglets were weaned at the age of 21 d and fed until the age of 49 d.
Serum, liver, and intestinal samples were obtained at 21, 28, and 49 d of age.
The results showed that LAB tended to decrease serum 8-hydroxy-2-deoxyguanosine concentration and decreased the concentration of serum and hepatic malondialdehyde, but increased the activity of hepatic glutathione peroxidase on days 21, 28, and 49.
The concentrations of secretory immunoglobulin A and some inflammatory cytokines and chemokines were increased (P<0.05) in the intestinal mucosa of LAB-treated piglets on days 21, 28, and 49 compared to that of CON piglets.
Likewise, protein expression of cyclooxygenase 2 and inducible nitric oxide synthase in the intestine of LAB-treated piglets was increased (P<0.05) during the whole period.
These results indicate that administration of LAB to the suckling piglet could improve antioxidant capacity and stimulate intestinal immune response, and these long-lasting effects are also observed up to 4 weeks after weaning.
A proper utilization of LAB to neonates would be beneficial to human and animal’s future health.
American Psychological Association (APA)
Li, Yinghui& Hou, Shuling& Peng, Wei& Lin, Qian& Chen, Fengming& Yang, Lingyuan…[et al.]. 2019. Oral Administration of Lactobacillus delbrueckii during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204906
Modern Language Association (MLA)
Li, Yinghui…[et al.]. Oral Administration of Lactobacillus delbrueckii during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1204906
American Medical Association (AMA)
Li, Yinghui& Hou, Shuling& Peng, Wei& Lin, Qian& Chen, Fengming& Yang, Lingyuan…[et al.]. Oral Administration of Lactobacillus delbrueckii during the Suckling Phase Improves Antioxidant Activities and Immune Responses after the Weaning Event in a Piglet Model. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204906