Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma
Joint Authors
Pan, Shu-Ting
Xue, Danfeng
Zhou, Xiongming
Ye, Fangfei
Zhou, Qun
Shi, Fanzhe
He, Fei
Yu, Hui
Qiu, Jiaxuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-26
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Cisplatin is widely used in the treatment of tongue squamous cell carcinoma (TSCC), but its clinical efficacy is limited by drug resistance and toxic side effects.
Hence, a novel compound capable of enhancing the anticancer effect of cisplatin while reducing the side effects is urgently needed.
We have previously shown that plumbagin (PLB), an anticancer phytochemical, is able to inhibit the growth of TSCC in vitro and in vivo.
The objective of this study was to investigate the effect of PLB in reversing the resistance of TSCC to cisplatin as well as its molecular mechanisms.
Here, we found that PLB enhances cisplatin-induced cytotoxicity, apoptosis, and autophagy in CAL27 and cisplatin-resistant CAL27/CDDP cells.
PLB could inhibit the viability and growth of TSCC cells by increasing the production of intracellular reactive oxygen species (ROS).
In addition, the combination treatment of PLB and cisplatin resulted in a synergistic inhibition of TSCC viability, apoptosis, and autophagy by increasing intracellular ROS, which may be achieved by activating JNK and inhibiting AKT/mTOR signaling pathways.
Finally, the synergistic treatment was also demonstrated in vivo.
Therefore, PLB combined with cisplatin is a potential therapeutic strategy against therapy TSCC cisplatin resistance.
American Psychological Association (APA)
Xue, Danfeng& Pan, Shu-Ting& Zhou, Xiongming& Ye, Fangfei& Zhou, Qun& Shi, Fanzhe…[et al.]. 2020. Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204913
Modern Language Association (MLA)
Xue, Danfeng…[et al.]. Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1204913
American Medical Association (AMA)
Xue, Danfeng& Pan, Shu-Ting& Zhou, Xiongming& Ye, Fangfei& Zhou, Qun& Shi, Fanzhe…[et al.]. Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204913