Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo
Joint Authors
Tomaszewska, Katarzyna
Kozłowska, Magdalena
Kaszuba, Andrzej
Narbutt, Joanna
Zalewska-Janowska, Anna
Lesiak, Aleksandra
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Alopecia areata (AA) and vitiligo are both common skin diseases of autoimmune origin.
Both alopecia areata and vitiligo have shown to be affected by oxidative stress.
The present work is aimed at evaluating and comparing the serum proinflammatory cytokine levels in AA and nonsegmental vitiligo (NSV).
A cross-sectional study was conducted of 33 patients with AA, 30 patients with NSV, and 30 healthy controls.
Serum levels of interferon γ (IFN-γ), interleukin- (IL-) 1β, and IL-6 were determined quantitatively by ELISA method.
Our analysis identified a signature of oxidative stress associated with AA and NSV, characterized by elevated levels of IFN-γ (AA: p=0.007283; NSV: p=0.038467), IL-1β (AA; NSV: p≤0.001), and IL-6 (AA; NSV: p≤0.001).
IL-6 was also significantly increased in NSV patients in comparison with AA patients (p=0.004485).
Our results supported the hypothesis that oxidative stress may play a significant role in promoting and amplifying the inflammatory process both in AA and vitiligo.
The complex understanding of both disease etiopathogenesis involves interrelationships between oxidative stress and autoimmunity.
The clinical study registration number is RNN/266/16/KE.
American Psychological Association (APA)
Tomaszewska, Katarzyna& Kozłowska, Magdalena& Kaszuba, Andrzej& Lesiak, Aleksandra& Narbutt, Joanna& Zalewska-Janowska, Anna. 2020. Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1204918
Modern Language Association (MLA)
Tomaszewska, Katarzyna…[et al.]. Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1204918
American Medical Association (AMA)
Tomaszewska, Katarzyna& Kozłowska, Magdalena& Kaszuba, Andrzej& Lesiak, Aleksandra& Narbutt, Joanna& Zalewska-Janowska, Anna. Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1204918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204918