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The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor
Joint Authors
Cignarelli, Angelo
Perrini, Sebastio
Laviola, Luigi
D’Oria, Rossella
Schipani, Rossella
Natalicchio, Annalisa
Giorgino, F.
Leonardini, Anna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-14
Country of Publication
Egypt
No. of Pages
29
Main Subjects
Abstract EN
Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen, controlled by both enzymatic and nonenzymatic antioxidant defense systems.
In the heart, ROS play an important role in cell homeostasis, by modulating cell proliferation, differentiation, and excitation-contraction coupling.
Oxidative stress occurs when ROS production exceeds the buffering capacity of the antioxidant defense systems, leading to cellular and molecular abnormalities, ultimately resulting in cardiac dysfunction.
In this review, we will discuss the physiological sources of ROS in the heart, the mechanisms of oxidative stress-related myocardial injury, and the implications of experimental studies and clinical trials with antioxidant therapies in cardiovascular diseases.
American Psychological Association (APA)
D’Oria, Rossella& Schipani, Rossella& Leonardini, Anna& Natalicchio, Annalisa& Perrini, Sebastio& Cignarelli, Angelo…[et al.]. 2020. The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1204937
Modern Language Association (MLA)
D’Oria, Rossella…[et al.]. The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-29.
https://search.emarefa.net/detail/BIM-1204937
American Medical Association (AMA)
D’Oria, Rossella& Schipani, Rossella& Leonardini, Anna& Natalicchio, Annalisa& Perrini, Sebastio& Cignarelli, Angelo…[et al.]. The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-29.
https://search.emarefa.net/detail/BIM-1204937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204937