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The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids
Joint Authors
Khaper, Neelam
Khurana, Sandhya
Tai, T. C.
Lamothe, J.
Tharmalingam, S.
Williamson, C.
Byrne, C. J.
Mercier, S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The causes of hypertension are complex and involve both genetic and environmental factors.
Environment changes during fetal development have been linked to adult diseases including hypertension.
Studies show that timed in utero exposure to the synthetic glucocorticoid (GC) dexamethasone (Dex) results in the development of hypertension in adult rats.
Evidence suggests that in utero stress can alter patterns of gene expression, possibly a result of alterations in the topology of the genome by epigenetic markers such as DNA methyltransferases (DNMTs) and histone deacetylases (HDACs).
The objective of this study was to determine the effects of epigenetic regulators in the fetal programming and the development of adult hypertension.
Specifically, this research examined the effects of the HDAC inhibitor valproic acid (VPA) and the DNMT inhibitor 5-aza-2′-deoxycytidine (5aza2DC) on blood pressure (BP) and gene expression in prenatal Dex-programmed rats.
Data suggest that both VPA and 5aza2DC attenuated the Dex-mediated development of hypertension and restored BP to control levels.
Epigenetic DNMT inhibition (DNMTi) or HDAC inhibition (HDACi) also successfully attenuated elevations in the majority of altered catecholamine (CA) enzyme expression, phenylethanolamine N-methyltransferase (PNMT) protein, and elevated epinephrine (Epi) levels in males.
Although females responded to HDACi similar to males, DNMTi drove increased glucocorticoid receptor (GR) and PNMT expression and elevations in circulating Epi in females despite showing normotensive BP.
American Psychological Association (APA)
Lamothe, J.& Khurana, Sandhya& Tharmalingam, S.& Williamson, C.& Byrne, C. J.& Khaper, Neelam…[et al.]. 2020. The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204941
Modern Language Association (MLA)
Lamothe, J.…[et al.]. The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1204941
American Medical Association (AMA)
Lamothe, J.& Khurana, Sandhya& Tharmalingam, S.& Williamson, C.& Byrne, C. J.& Khaper, Neelam…[et al.]. The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204941