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Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction
Joint Authors
Filippelli, Amelia
Conti, V.
Manzo, V.
Vecchione, Carmine
Carrizzo, Albino
Ferrara, Nicola
Troisi, Jacopo
Colucci, Angelo
Di Pietro, Paola
Calabrese, Maria Consiglia
Corbi, Graziamaria
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Exercise training induces beneficial effects also by increasing levels of Sirtuin 1 (Sirt1) and β-hydroxybutyrate (βOHB).
Up to date, no studies investigated the role of exercise training-based cardiac rehabilitation (ET-CR) programs on βOHB levels.
Therefore, the present study is aimed at investigating whether a supervised 4-week ET-CR program was able to induce changes in Sirt1 activity and βOHB levels and to evaluate the possible relationship between such parameters, in Heart Failure with preserved Ejection Fraction (HFpEF) patients.
Methods.
A prospective longitudinal observational study was conducted on patients consecutively admitted to the Cardiology and Cardiac Rehabilitation Units of “San Gennaro dei Poveri” Hospital in Naples, Italy.
In fifty elderly patients affected by HFpEF, in NYHA II and III class, Sirt1 activity, Trolox Equivalent Antioxidant Capacity (TEAC), βOHB, and Oxidized Low-Density Lipoprotein (Ox-LDL) levels were measured before and at the end of the ET-CR program.
A control group of 20 HFpEF patients was also recruited, and the same parameters were evaluated 4 weeks after the beginning of the study.
Results.
ET-CR induced an increase of Sirt1 activity, βOHB levels, and antioxidant capacity.
Moreover, it was associated with a rise in NAD+ and NAD+/NADH ratio levels and a reduction in Ox-LDL.
No changes affected the controls.
Conclusion.
The characterization of the ET-CR effects from a metabolic viewpoint might represent an important step to improve the HFpEF management.
American Psychological Association (APA)
Corbi, Graziamaria& Conti, V.& Troisi, Jacopo& Colucci, Angelo& Manzo, V.& Di Pietro, Paola…[et al.]. 2019. Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204947
Modern Language Association (MLA)
Corbi, Graziamaria…[et al.]. Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1204947
American Medical Association (AMA)
Corbi, Graziamaria& Conti, V.& Troisi, Jacopo& Colucci, Angelo& Manzo, V.& Di Pietro, Paola…[et al.]. Cardiac Rehabilitation Increases SIRT1 Activity and β-Hydroxybutyrate Levels and Decreases Oxidative Stress in Patients with HF with Preserved Ejection Fraction. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204947