Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress
Joint Authors
Wang, Zhiwei
Li, Bowen
Hu, Zhipeng
Ruan, Yongle
Wu, Qi
Hong, Junmou
Hu, Junxia
Chen, Ruoshi
Hu, Xiaoping
Zhang, Zhengpei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-09
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Ribosome biogenesis is a crucial biological process related to cell proliferation, redox balance, and muscle contractility.
Aortic smooth muscle cells (ASMCs) show inhibition of proliferation and apoptosis, along with high levels of oxidative stress in aortic dissection (AD).
Theoretically, ribosome biogenesis should be enhanced in the ASMCs at its proliferative state but suppressed during apoptosis and oxidative stress.
However, the exact status and role of ribosome biogenesis in AD are unknown.
We therefore analyzed the expression levels of BOP1, a component of the PeBoW complex which is crucial to ribosome biogenesis, in AD patients and a murine AD model and its influence on the ASMCs.
BOP1 was downregulated in the aortic tissues of AD patients compared to healthy donors.
In addition, overexpression of BOP1 in human aortic smooth muscle cells (HASMCs) inhibited apoptosis and accumulation of p53 under hypoxic conditions, while knockdown of BOP1 decreased the protein synthesis rate and motility of HASMCs.
The RNA polymerase I inhibitor cx-5461 induced apoptosis, ROS production, and proliferative inhibition in the HASMCs, which was partly attenuated by p53 knockout.
Furthermore, cx-5461 aggravated the severity of AD in vivo, but a p53-/- background extended the life-span and lowered AD incidence in the mice.
Taken together, decreased ribosome biogenesis in ASMCs resulting in p53-dependent proliferative inhibition, oxidative stress, and apoptosis is one of the underlying mechanisms of AD.
American Psychological Association (APA)
Wu, Qi& Hong, Junmou& Wang, Zhiwei& Hu, Junxia& Chen, Ruoshi& Hu, Zhipeng…[et al.]. 2019. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204963
Modern Language Association (MLA)
Wu, Qi…[et al.]. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1204963
American Medical Association (AMA)
Wu, Qi& Hong, Junmou& Wang, Zhiwei& Hu, Junxia& Chen, Ruoshi& Hu, Zhipeng…[et al.]. Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204963