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Systematical Identification of the Protective Effect of Danhong Injection and BuChang NaoXinTong Capsules on Transcription Factors in Cerebral Ischemia Mice Brain
Joint Authors
Wu, Hongwei
Zhang, Yi
Wang, Tingting
Xu, Jing
Guo, Feifei
Ji, Enhui
Tang, Shihuan
Wei, Junying
Yang, Hongjun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cerebral ischemia has led to a high rate of both disability and mortality with massive healthcare costs.
Although transcriptional regulation is typically mediated by different combinations of TFs, a combined regulatory unit to synergistically activate transcription has remained unclear in cerebral ischemia, especially in different drug treatments.
In this study, TFs alterations after 6 h cerebral ischemic injury and repair were performed by a concatenated tandem array of consensus transcription factor response elements (catTFREs), and vital TFs were obtained by TFs-target imbalanced network.
Drug intervention used Danhong injection (DHI) and BNC (BuChang NaoXinTong Capsules), which has been widely prescribed in Chinese herb medicine for the treatment of cerebrovascular and cardiovascular diseases.
There were 198 TFs identified after 6 h MCAO operation, and six TFs (Sox2, Smad3, FoxO1, Creb1, Egr,1 and Smad4) were considered as critical TFs in response to cerebral ischemia.
Moreover, Smad3 was identified as a hub TF among six vital TFs, and the transcription activity of Smad3 was further verified.
These 6 TFs were all reversed by DHI or BNC, indicating different medications may regulate different transcription factors through TF synergy.
Moreover, validation results indicated that Smad3 was a putative target TF for DHI and BNC-mediated protection against cerebral ischemia.
The observations of the present study provide a fresh understanding of biomolecules and possible new avenues for therapeutic interventions, in addition to the new intervention pattern for different treatments for ischemia stroke.
American Psychological Association (APA)
Xu, Jing& Wang, Tingting& Guo, Feifei& Ji, Enhui& Zhang, Yi& Wu, Hongwei…[et al.]. 2020. Systematical Identification of the Protective Effect of Danhong Injection and BuChang NaoXinTong Capsules on Transcription Factors in Cerebral Ischemia Mice Brain. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204973
Modern Language Association (MLA)
Xu, Jing…[et al.]. Systematical Identification of the Protective Effect of Danhong Injection and BuChang NaoXinTong Capsules on Transcription Factors in Cerebral Ischemia Mice Brain. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1204973
American Medical Association (AMA)
Xu, Jing& Wang, Tingting& Guo, Feifei& Ji, Enhui& Zhang, Yi& Wu, Hongwei…[et al.]. Systematical Identification of the Protective Effect of Danhong Injection and BuChang NaoXinTong Capsules on Transcription Factors in Cerebral Ischemia Mice Brain. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204973