Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model
Joint Authors
Tavalaee, Marziyeh
Nasr-Esfahani, Mohammad H.
Hosseini, Mahshid
Shaygannia, Erfaneh
Rahmani, Mohsen
Eskandari, Anahita
Golsefid, Aram Ahmadzadeh
Gharagozloo, Parviz
Drevet, J. R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Using a surgically induced varicocele rat model, we show here strong evidence that the misfolded/unfolded protein response that is part of the stress response of the endoplasmic reticulum (ER) is activated in the varicocele testis (VCL), leading to the induction of apoptosis.
To support this hypothesis, it is observed that the spliced variant of the X-box protein 1 (XBP1s), resulting from the activation of the inositol-requiring enzyme 1 (IRE1) membrane sensor, is significantly more represented in VCL testicular extracts.
The activation of the IRE1/XBP1s pathway is also supported by the observation that the VCL testes show an increase phosphorylation of the c-Jun-kinase (JNK) known to be one intermediate of this pathway and an increased level of caspase-3, the terminal apoptotic effector, partly explaining the apoptotic status of the VCL testis.
American Psychological Association (APA)
Hosseini, Mahshid& Shaygannia, Erfaneh& Rahmani, Mohsen& Eskandari, Anahita& Golsefid, Aram Ahmadzadeh& Tavalaee, Marziyeh…[et al.]. 2020. Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204978
Modern Language Association (MLA)
Hosseini, Mahshid…[et al.]. Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1204978
American Medical Association (AMA)
Hosseini, Mahshid& Shaygannia, Erfaneh& Rahmani, Mohsen& Eskandari, Anahita& Golsefid, Aram Ahmadzadeh& Tavalaee, Marziyeh…[et al.]. Endoplasmic Reticulum Stress (ER Stress) and Unfolded Protein Response (UPR) Occur in a Rat Varicocele Testis Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1204978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204978