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Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural StemProgenitor Cells through Upregulating Glycolytic Flux and Redox Potential
Joint Authors
Kang, Mingyu
Cho, Jin-Hwa
Kim, Tae-Jun
Lee, Sang Min
Kim, Hyeon Ji
Coronado, Indiana
Yi, Dong-Keun
Kim, Do-Yeon
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS).
Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases.
The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs.
In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis.
We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential.
On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation.
Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential.
American Psychological Association (APA)
Kang, Mingyu& Cho, Jin-Hwa& Kim, Tae-Jun& Lee, Sang Min& Kim, Hyeon Ji& Coronado, Indiana…[et al.]. 2020. Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural StemProgenitor Cells through Upregulating Glycolytic Flux and Redox Potential. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205000
Modern Language Association (MLA)
Kang, Mingyu…[et al.]. Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural StemProgenitor Cells through Upregulating Glycolytic Flux and Redox Potential. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205000
American Medical Association (AMA)
Kang, Mingyu& Cho, Jin-Hwa& Kim, Tae-Jun& Lee, Sang Min& Kim, Hyeon Ji& Coronado, Indiana…[et al.]. Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural StemProgenitor Cells through Upregulating Glycolytic Flux and Redox Potential. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205000