Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge
Joint Authors
Huang, Xingguo
Li, Yinghui
Chen, Fengming
Wang, Houjun
Chen, Jiayi
Liu, Yang
Wen, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study was conducted to evaluate the effect of dietary supplementation with Lactobacillus delbrueckii (LAB) on intestinal morphology, barrier function, immune response, and antioxidant capacity in weaned piglets challenged with lipopolysaccharide (LPS).
A total of 36 two-line crossbred (Landrace × large Yorkshire) weaned piglets (28 days old) were divided into three groups: (1) nonchallenged control (CON); (2) LPS-challenged control (LPS); and (3) LAB+LPS treatment (0.2% LAB+LPS).
Compared to the LPS piglets, the LAB+LPS piglets improved intestinal morphology, indicated by greater (P<0.05) villus height in the duodenum and ileum; villus height : crypt depth ratio in the duodenum, jejunum, and ileum, as well as decreased (P<0.05) crypt depth in the jejunum and ileum; and better intestinal barrier function, indicated by upregulated (P<0.05) mRNA expression of tight junction proteins in the intestinal mucosa.
Moreover, compared to the LPS piglets, LAB significantly decreased (P<0.05) concentrations of TNF-α and IL-1β in the small intestine and increased (P<0.05) IL-10 levels in the jejunum and ileum.
Additionally, LAB increased (P<0.05) T-AOC activities of the colon, GSH concentrations of the jejunum, and mRNA expression of CAT and Cu/Zn-SOD, while reduced (P<0.05) MDA concentrations in the jejunum and ileum in LPS-changed piglets.
Collectively, our results indicate that supplementation of LAB improved intestinal integrity and immune response and alleviated intestinal oxidative damage in LPS-challenged piglets.
American Psychological Association (APA)
Chen, Fengming& Wang, Houjun& Chen, Jiayi& Liu, Yang& Wen, Wei& Li, Yinghui…[et al.]. 2020. Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205010
Modern Language Association (MLA)
Chen, Fengming…[et al.]. Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205010
American Medical Association (AMA)
Chen, Fengming& Wang, Houjun& Chen, Jiayi& Liu, Yang& Wen, Wei& Li, Yinghui…[et al.]. Lactobacillus delbrueckii Ameliorates Intestinal Integrity and Antioxidant Ability in Weaned Piglets after a Lipopolysaccharide Challenge. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205010