Comparison of Oxidative Stress Parameters in Heart Failure Patients Depending on Ischaemic or Nonischaemic Aetiology

Abstract EN

Background.

Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis.

Aim of Study.

The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopathy (ICM) (n=479) and nonischaemic cardiomyopathy (nICM) (n=295) patients; assessment of the relationships of OSP with functional capacity (NYHA class), maximal oxygen consumption (max.O2), left ventricle ejection fraction (LVEF), and NT-proBNP concentration; and determination of the mutual relations of OSP in subgroups of patients with ICM and n-ICM.

Methods.

Serum concentrations of total antioxidant capacity (TAC), total oxidant status (TOS), uric acid (UA), bilirubin, albumin, protein sulfhydryl groups (PSH), and malondialdehyde (MDA) were measured.

The oxidative stress index (OSI) and MDA/PSH ratio were calculated.

Results.

Higher concentrations of TAC (1.14 vs 1.11 mmol/l; p<0.001) and MDA (1.80 vs 1.70 μmol/l; p<0.05) and higher MDA/PSH ratios (0.435 vs 0.358; p<0,001) were observed in ICM than in nICM patients.

Simultaneously, lower values of the OSI index (4.27 vs 4.6; p<0,05), PSH (4.10 vs 4.75 μmol/g of protein; p<0,001), and bilirubin (12.70 vs 15.40 μmol/l; p<0,001) concentrations were indicated in ICM patients.

There were no differences in TOS, UA, and albumin between the examined groups.

The NYHA class and VO2max correlate with MDA, bilirubin, and albumin in both groups, while with UA only in the ICM group.

Correlations between the NYHA class, VO2max, and PSH were indicated in nICM.

The association of LVEF with UA, bilirubin, and albumin has been demonstrated in the ICM group.

The study showed negative correlations between TAC, MDA, and PSH and positive between TAC and MDA in both groups.

In ICM patients, MDA positively correlated with UA.

A negative correlation between PSH and concentrations of UA and bilirubin was expressed only in the nICM group.

Conclusion.

The obtained results confirm the relationship between the severity of HF and oxidative stress.

The mechanisms of oxidative stress and antioxidant defence are partially different in the ICM and the nICM patients.