Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress
Joint Authors
Lu, Chengrong
Liu, Xiaoyi
Fan, Lihong
Yin, Shutao
Hu, Hongbo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The nuclear transcription factor p53, discovered in 1979, has a broad range of biological functions, primarily the regulation of apoptosis, the cell cycle, and DNA repair.
In addition to these canonical functions, a growing body of evidence suggests that p53 plays an important role in regulating intracellular redox homeostasis through transcriptional and nontranscriptional mechanisms.
Oxidative stress induction and p53 activation are common responses to chemical exposure and are suggested to play critical roles in chemical-induced toxicity.
The activation of p53 can exert either prooxidant or antioxidant activity, depending on the context.
In this review, we discuss the functional role of p53 in regulating chemical-induced oxidative stress, summarize the potential signaling pathways involved in p53’s regulation of chemically mediated oxidative stress, and propose issues that should be addressed in future studies to improve understanding of the relationship between p53 and chemical-induced oxidative stress.
American Psychological Association (APA)
Liu, Xiaoyi& Fan, Lihong& Lu, Chengrong& Yin, Shutao& Hu, Hongbo. 2020. Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205016
Modern Language Association (MLA)
Liu, Xiaoyi…[et al.]. Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205016
American Medical Association (AMA)
Liu, Xiaoyi& Fan, Lihong& Lu, Chengrong& Yin, Shutao& Hu, Hongbo. Functional Role of p53 in the Regulation of Chemical-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205016