Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38MAPK and Wntβ-Catenin Signaling Pathways
Joint Authors
Wu, Xiuhua
Liu, Yang
Zhang, Enfan
Chen, Jing
Huang, Xi
Yan, Haimeng
Cao, Wen
Qu, Jianwei
Gu, Huiyao
Xu, Ruyi
He, Jingsong
Cai, Zhen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Dihydroartemisinin (DHA), an active metabolite and derivative of artemisinin, is the most effective antimalarial drug and has strong antitumor activity in various tumor types.
It has recently been reported that DHA can induce autophagy and has significant effects on multiple myeloma (MM), but the mechanisms and the relationship between the autophagy and apoptosis induced by DHA remain to be elucidated.
Herein, we demonstrated that DHA significantly induces cell death in a dose- and time-dependent manner via the extrinsic and intrinsic apoptosis pathways.
Moreover, DHA-induced autophagy, which plays a prodeath role in MM, can regulate canonical apoptosis and vice versa.
Furthermore, the P38/MAPK signaling pathway is responsible for decreased autophagy and increased apoptosis.
DHA induces autophagy and apoptosis also through the inhibition of the Wnt/β-catenin signaling pathway.
In addition, DHA shows a strong effect in a xenograft mouse model.
Collectively, these findings reveal that DHA, as an artemisinin-based drug, could be an effective and safe therapeutic agent for MM.
American Psychological Association (APA)
Wu, Xiuhua& Liu, Yang& Zhang, Enfan& Chen, Jing& Huang, Xi& Yan, Haimeng…[et al.]. 2020. Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38MAPK and Wntβ-Catenin Signaling Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205048
Modern Language Association (MLA)
Wu, Xiuhua…[et al.]. Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38MAPK and Wntβ-Catenin Signaling Pathways. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205048
American Medical Association (AMA)
Wu, Xiuhua& Liu, Yang& Zhang, Enfan& Chen, Jing& Huang, Xi& Yan, Haimeng…[et al.]. Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38MAPK and Wntβ-Catenin Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205048