Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal IschemiaReperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-KinaseAkt Pathway
Joint Authors
Yan, Xuetao
Song, Zhengyang
Chen, Meng
Tang, Jun-Jiao
Zhang, Zong-Ze
He, Xiang-Hu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Intestinal ischemia/reperfusion (I/R) is a clinical emergency, which often causes lung injury with high morbidity and mortality.
Although dexmedetomidine has been identified to have a protective effect on lung injury caused by intestinal I/R, its specific mechanism is still elucidated.
In recent years, the cannabinoid (CB2) receptor pathway has been found to be involved in I/R injury of some organs.
In the current study, we investigated whether the CB2 receptor pathway contributes to the protective effect of dexmedetomidine on the intestinal I/R-induced lung injury in rats.
Dexmedetomidine treatment upregulated the expression of CB2 receptor and suppressed the I/R-induced increases in lung injury scores, inflammatory cell infiltration, lung wet/dry ratio, MPO activity, MDA level, inflammatory cytokines, and caspase-3 expression while augmenting SOD activity and Bcl-2 expression, indicating attenuation of lung injury.
Dexmedetomidine treatment also increased the expression of Akt.
The protective effects of dexmedetomidine treatment were reversed by the CB2 receptor antagonist AM630 or the PI3K inhibitor wortmannin.
And the CB2 receptor antagonist AM630 also downregulated the expression of Akt.
Thus, our findings suggest that treatment with dexmedetomidine provides a protective role against lung injury caused by intestinal I/R in rats, possibly due to the upregulation of the CB2 receptor, followed by the activation of the PI3K/Akt pathway.
American Psychological Association (APA)
Chen, Meng& Yan, Xuetao& Song, Zhengyang& Tang, Jun-Jiao& Zhang, Zong-Ze& He, Xiang-Hu. 2020. Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal IschemiaReperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-KinaseAkt Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205059
Modern Language Association (MLA)
Chen, Meng…[et al.]. Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal IschemiaReperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-KinaseAkt Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205059
American Medical Association (AMA)
Chen, Meng& Yan, Xuetao& Song, Zhengyang& Tang, Jun-Jiao& Zhang, Zong-Ze& He, Xiang-Hu. Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal IschemiaReperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-KinaseAkt Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205059