Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPKNrf-2HO-1NF-κB In Vitro and In Vivo
Joint Authors
Ye, Qing
Wang, Chenyi
Wang, Fei
Wang, Shuo
Li, Wei-Nan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to investigate the cardioprotective effect of mangiferin (MAF) in vitro and in vivo.
Oxidative stress and inflammatory injury were detected in coronary artery ligation in rats and also in hypoxia-reoxygenation- (H/R-) induced H9c2 cells.
MAF inhibited myocardial oxidative stress and proinflammatory cytokines in rats with coronary artery occlusion.
The ST segment of MAF treatment groups also resumed.
Triphenyltetrazolium chloride (TTC) staining and pathological analysis showed that MAF could significantly reduce myocardial injury.
In vitro data showed that MAF could improve hypoxia/reoxygenation- (H/R-) induced H9c2 cell activity.
In addition, MAF could significantly reduce oxidative stress and inflammatory pathway protein expression in H/R-induced H9c2 cells.
This study has clarified the protective effects of MAF on myocardial injury and also confirmed that oxidative stress and inflammation were involved in the myocardial ischemia-reperfusion injury (I/R) model.
American Psychological Association (APA)
Wang, Chenyi& Wang, Fei& Wang, Shuo& Li, Wei-Nan& Ye, Qing. 2019. Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPKNrf-2HO-1NF-κB In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205100
Modern Language Association (MLA)
Wang, Chenyi…[et al.]. Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPKNrf-2HO-1NF-κB In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205100
American Medical Association (AMA)
Wang, Chenyi& Wang, Fei& Wang, Shuo& Li, Wei-Nan& Ye, Qing. Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury via MAPKNrf-2HO-1NF-κB In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205100