AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of ProoxidantAntioxidant Mechanisms
Joint Authors
Gajdosechová, Lucia
Olszanecki, Rafał
Dobrocsyova, Viktoria
Slamkova, Miroslava
Krskova, Katarina
Suski, Maciej
Cacanyiova, Sona
Zorad, Stefan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Angiotensin 1-7 (Ang 1-7) enhances insulin signaling and glucose transport activity in the skeletal muscle.
The aim of our study was to evaluate the effect of AVE0991, a nonpeptide Mas receptor agonist, on the metabolic parameters, expression of RAS components and markers of oxidative stress, and insulin signaling in the skeletal morbidly obese rats.
33-week-old male obese Zucker rats were treated with vehicle and AVE0991 (0.5 mg/kg BW/day) via osmotic minipumps for two weeks.
Gene expressions were determined by qPCR and/or Western blot analysis in musculus quadriceps.
The enzymatic activities were detected flourometrically (aminopeptidase A) or by colorimetric assay kit (protein tyrosine phosphatase 1B).
Administration of AVE0991 enhanced insulin signaling cascade in the skeletal muscle, reflected by improved whole-body glucose tolerance.
It has been shown that reactive oxygen species (ROS) have insulin-mimetic action in muscle.
The expression of renin receptor, transcription factor PLZF, and prooxidant genes was upregulated by AVE0991 accompanied by elevated expression of genes coding enzymes with antioxidant action.
Our results show that AVE0991 administration activates genes involved in both ROS generation and clearance establishing a new prooxidant/antioxidant balance on a higher level, which might contribute to the improved insulin signaling pathway and glucose tolerance of obese Zucker rats.
American Psychological Association (APA)
Dobrocsyova, Viktoria& Slamkova, Miroslava& Krskova, Katarina& Gajdosechová, Lucia& Suski, Maciej& Olszanecki, Rafał…[et al.]. 2020. AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of ProoxidantAntioxidant Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205103
Modern Language Association (MLA)
Dobrocsyova, Viktoria…[et al.]. AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of ProoxidantAntioxidant Mechanisms. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205103
American Medical Association (AMA)
Dobrocsyova, Viktoria& Slamkova, Miroslava& Krskova, Katarina& Gajdosechová, Lucia& Suski, Maciej& Olszanecki, Rafał…[et al.]. AVE0991, a Nonpeptide Angiotensin 1-7 Receptor Agonist, Improves Glucose Metabolism in the Skeletal Muscle of Obese Zucker Rats: Possible Involvement of ProoxidantAntioxidant Mechanisms. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205103