Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro
Joint Authors
Sadowska-Bartosz, Izabela
Bartosz, Grzegorz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Replicative senescence is an unalterable growth arrest of primary cells in the culture system.
It has been reported that aging in vivo is related to the limited replicative capacity that normal somatic cells show in vitro.
If oxidative damage contributes to the lifespan limitation, antioxidants are expected to extend the replicative lifespan of fibroblasts.
This article critically reviews the results of experiments devoted to this problem performed within the last decades under conditions of in vitro culture.
The results of studied are heterogeneous, some papers showing no effects of antioxidants; most finding limited enhancement of reproductive capacity of fibroblasts, some reporting a significant extension of replicative lifespan (RLS).
Both natural and synthetic antioxidants were found to extend the RLS of fibroblasts, either by a direct antioxidant effect or, indirectly, by activation of signaling pathways and activation of proteasomes or hormetic effects.
Most significant prolongation of RLS was reported so far for nicotinamide, N-hydroxylamines, carnosine and Methylene Blue.
These results may be of importance for the design of skin-protecting cosmetics.
American Psychological Association (APA)
Sadowska-Bartosz, Izabela& Bartosz, Grzegorz. 2020. Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205123
Modern Language Association (MLA)
Sadowska-Bartosz, Izabela& Bartosz, Grzegorz. Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205123
American Medical Association (AMA)
Sadowska-Bartosz, Izabela& Bartosz, Grzegorz. Effect of Antioxidants on the Fibroblast Replicative Lifespan In Vitro. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205123