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The Signaling of Cellular Senescence in Diabetic Nephropathy
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-03
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries.
Notably, it has a rapidly rising prevalence in China.
The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (ESRD) and death.
However, the pathogenic mechanisms of diabetic nephropathy have not been determined.
Cellular senescence, which recently has gained broad attention, is thought to be an important player in the onset and development of diabetic nephropathy.
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/β-catenin signaling activation, persistent inflammation, and accumulation of uremic toxins.
Moreover, we highlight the potential therapeutic targets of cellular senescence in diabetic nephropathy and provide important clues for clinical strategies.
American Psychological Association (APA)
Xiong, Yabing& Zhou, Lili. 2019. The Signaling of Cellular Senescence in Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205166
Modern Language Association (MLA)
Xiong, Yabing& Zhou, Lili. The Signaling of Cellular Senescence in Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1205166
American Medical Association (AMA)
Xiong, Yabing& Zhou, Lili. The Signaling of Cellular Senescence in Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1205166
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205166