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Renalase Attenuates Mouse Fatty Liver IschemiaReperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1
Joint Authors
Li, Huili
Wang, Jiliang
Guo, Jianrong
Gu, Jian
Chen, Ke
Zhang, Tao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-16
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Liver ischemia/reperfusion (IR) injury is a severe complication of liver surgery.
Moreover, nonalcoholic fatty liver disease (NAFLD) patients are particularly vulnerable to IR injury, with higher rates of postoperative morbidity and mortality after liver surgeries.
Our previous study found that renalase (RNLS) was highly sensitive and responsive to oxidative stress, which may be a promising biomarker for the evaluation of the severity of liver IR injury.
However, the role of RNLS in liver IR injury remains unclear.
In the present study, we intensively explored the role and mechanism of RNLS in fatty liver IR injury in vivo and in vitro.
C57BL/6 mice were divided into 2 groups feeding with high-fat diet (HFD) and control diet (CD), respectively.
After 20 weeks’ feeding, they were suffered from portal triad blockage and reflow to induce liver IR injury.
Additionally, oleic acid (OA) and tert-butyl hydroperoxide (t-BHP) were used in vitro to induce steatotic hepatocytes and to simulate ROS burst and mimic cellular oxidative stress following portal triad blockage and reflow, respectively.
Our data showed that RNLS was downregulated in fatty livers, and RNLS administration effectively attenuated IR injury by reducing ROS production and improving mitochondrial function through activating SIRT1.
Additionally, the downregulation of RNLS in the fatty liver was mediated by a decrease of signal transduction and activator of transcription 3 (STAT3) expression under HFD conditions.
These findings make RNLS a promising therapeutic strategy for the attenuation of liver IR injury.
American Psychological Association (APA)
Zhang, Tao& Gu, Jian& Guo, Jianrong& Chen, Ke& Li, Huili& Wang, Jiliang. 2019. Renalase Attenuates Mouse Fatty Liver IschemiaReperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1205182
Modern Language Association (MLA)
Zhang, Tao…[et al.]. Renalase Attenuates Mouse Fatty Liver IschemiaReperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1205182
American Medical Association (AMA)
Zhang, Tao& Gu, Jian& Guo, Jianrong& Chen, Ke& Li, Huili& Wang, Jiliang. Renalase Attenuates Mouse Fatty Liver IschemiaReperfusion Injury through Mitigating Oxidative Stress and Mitochondrial Damage via Activating SIRT1. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1205182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205182