Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after E. coli Infection
Joint Authors
Huang, Chao
Liu, Wentao
Fang, Jing
Ou, Yangping
Geng, Yi
Chen, Zhengli
Wang, Fengyuan
Chen, Kejie
Guo, Hongrui
Cui, Hengmin
Zuo, Z. C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obesity has developed into a considerable health problem in the whole world.
Escherichia coli (E.
coli) can cause nosocomial pneumonia and induce cell apoptosis during injury and infection.
Normal (lean) and diet-induced obesity mice (DIO, fed with high-fat diet) were chosen to perform nasal instillation with E.
coli to establish a nonfatal acute pneumonia model.
At 0 h, 12 h, 24 h, and 72 h postinfection, lung tissues were obtained to measure cell apoptosis.
As shown in this study, both lean and DIO mice exhibited histopathological lesions of acute pneumonia and increased cell apoptosis in the lung infected with E.
coli.
Interestingly, the relative mRNA and protein expressions associated with either endoplasmic reticulum stress or death receptor apoptotic pathway were all dramatically increased in the DIO mice after infection, while only significant upregulation of death receptor apoptotic pathway in the lean mice at 72 h.
These results indicated that the DIO mice executed excess cell apoptosis in the nonfatal acute pneumonia induced by E.
coli infection through endoplasmic reticulum stress and death receptor apoptotic pathway.
American Psychological Association (APA)
Wang, Fengyuan& Zuo, Z. C.& Chen, Kejie& Fang, Jing& Cui, Hengmin& Geng, Yi…[et al.]. 2020. Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after E. coli Infection. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205218
Modern Language Association (MLA)
Wang, Fengyuan…[et al.]. Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after E. coli Infection. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205218
American Medical Association (AMA)
Wang, Fengyuan& Zuo, Z. C.& Chen, Kejie& Fang, Jing& Cui, Hengmin& Geng, Yi…[et al.]. Diet-Induced Obesity Mice Execute Pulmonary Cell Apoptosis via Death Receptor and ER-Stress Pathways after E. coli Infection. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205218