Effects of Plant and Animal Natural Products on Mitophagy
Joint Authors
Sahebkar, Amirhossein
Pirro, Matteo
Bianconi, Vanessa
Shakeri, Farzaneh
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitophagy is a protected cellular process that is essential for autophagic removal of damaged mitochondria and for preservation of a healthy mitochondrial population.
In the last years, a particular interest has been devoted in studying the effects of natural compounds on mitophagy.
Different natural compounds may modulate mitochondrial oxidative phosphorylation, the production of mitochondrial reactive oxygen species, the expression of mitophagy- and autophagy-related genes, and the activities of transcription factors which regulate the expression of mitochondrial proteins, thereby controlling mitochondrial damage and mitophagy.
Remarkably, since mitochondrial function has a crucial role in the pathogenesis of various diseases (e.g., cancer, atherosclerosis, Duchenne muscular dystrophy, diabetes complications, Alzheimer’s disease, and hepatic steatosis), these effects might have important therapeutic implications.
In this review, preclinical studies investigating the role of different natural compounds in the modulation of mitophagy will be discussed.
American Psychological Association (APA)
Shakeri, Farzaneh& Bianconi, Vanessa& Pirro, Matteo& Sahebkar, Amirhossein. 2020. Effects of Plant and Animal Natural Products on Mitophagy. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205249
Modern Language Association (MLA)
Shakeri, Farzaneh…[et al.]. Effects of Plant and Animal Natural Products on Mitophagy. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1205249
American Medical Association (AMA)
Shakeri, Farzaneh& Bianconi, Vanessa& Pirro, Matteo& Sahebkar, Amirhossein. Effects of Plant and Animal Natural Products on Mitophagy. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1205249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205249