Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling
Joint Authors
Yu, Zaixin
Li, Tangzhiming
Li, Suqi
Feng, Yilu
Zeng, Xiaofang
Dong, Shaohong
Li, Jianghua
Zha, Lihuang
Luo, Hui
Zhao, Lin
Liu, Bin
Ou, Ziwei
Lin, Wenchao
Zhang, Mengqiu
Li, Sheng
Jiang, Qiuqiong
Qi, Qiangqiang
Xu, Qingyao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Pulmonary arterial hypertension (PAH) is a lethal disease generally characterized by pulmonary artery remodeling.
Mitochondrial metabolic disorders have been implicated as a critical regulator of excessively proliferative- and apoptosis-resistant phenotypes in pulmonary artery smooth muscle cells (PASMCs).
Dichloroacetate (DCA) is an emerging drug that targets aerobic glycolysis in tumor cells.
Atorvastatin (ATO) is widely used for hyperlipemia in various cardiovascular diseases.
Considering that DCA and ATO regulate glucose and lipid metabolism, respectively, we hypothesized that the combination of DCA and ATO could be a potential treatment for PAH.
A notable decrease in the right ventricular systolic pressure accompanied by reduced right heart hypertrophy was observed in the DCA/ATO combination treatment group compared with the monocrotaline treatment group.
The DCA/ATO combination treatment alleviated vascular remodeling, thereby suppressing excessive PASMC proliferation and macrophage infiltration.
In vitro, both DCA and ATO alone reduced PASMC viability by upregulating oxidative stress and lowering mitochondrial membrane potential.
Surprisingly, when combined, DCA/ATO was able to decrease the levels of reactive oxygen species and cell apoptosis without compromising PASMC proliferation.
Furthermore, suppression of the p38 pathway through the specific inhibitor SB203580 attenuated cell death and oxidative stress at a level consistent with that of DCA/ATO combination treatment.
These observations suggested a complementary effect of DCA and ATO on rescuing PASMCs from a PAH phenotype through p38 activation via the regulation of mitochondrial-related cell death and oxidative stress.
DCA in combination with ATO may represent a novel therapeutic strategy for PAH treatment.
American Psychological Association (APA)
Li, Tangzhiming& Li, Suqi& Feng, Yilu& Zeng, Xiaofang& Dong, Shaohong& Li, Jianghua…[et al.]. 2020. Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205251
Modern Language Association (MLA)
Li, Tangzhiming…[et al.]. Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205251
American Medical Association (AMA)
Li, Tangzhiming& Li, Suqi& Feng, Yilu& Zeng, Xiaofang& Dong, Shaohong& Li, Jianghua…[et al.]. Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205251