Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function
Joint Authors
Silva-Platas, Christian
Torres-Quintanilla, Alejandro
Garcia-Rivas, Gerardo
Bernal-Ramírez, Judith
Lozano, Omar
Lázaro-Alfaro, Anay
Oropeza-Almazán, Yuriana
Alves-Figueiredo, Hugo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The effective delivery of antioxidants to the cells is hindered by their high metabolization rate.
In this work, quercetin was encapsulated in poly(lactic-co-glycolic) acid (PLGA) nanoparticles.
They were characterized in terms of its physicochemical properties (particle size distribution, ζ-potential, encapsulation efficiency, quercetin release and biological interactions with cardiac cells regarding nanoparticle association, and internalization and protective capability against relevant challenges).
A better delivery of quercetin was achieved when encapsulated versus free.
When the cells were challenged with antimycin A, it resulted in lower mitochondrial O2- (4.65- vs.
5.69- fold) and H2O2 rate production (1.15- vs.
1.73- fold).
Similarly, under hypoxia-reoxygenation injury, a better maintenance of cell viability was found (77 vs.
65%), as well as a reduction of thiol groups (~70 vs.
40%).
Therefore, the delivery of encapsulated quercetin resulted in the preservation of mitochondrial function and ATP synthesis due to its improved oxidative stress suppression.
The results point to the potential of this strategy for the treatment of oxidative stress-based cardiac diseases.
American Psychological Association (APA)
Lozano, Omar& Lázaro-Alfaro, Anay& Silva-Platas, Christian& Oropeza-Almazán, Yuriana& Torres-Quintanilla, Alejandro& Bernal-Ramírez, Judith…[et al.]. 2019. Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205252
Modern Language Association (MLA)
Lozano, Omar…[et al.]. Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205252
American Medical Association (AMA)
Lozano, Omar& Lázaro-Alfaro, Anay& Silva-Platas, Christian& Oropeza-Almazán, Yuriana& Torres-Quintanilla, Alejandro& Bernal-Ramírez, Judith…[et al.]. Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205252