Epicatechin Gallate Protects HBMVECs from IschemiaReperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization
Joint Authors
Fu, Bing
Zeng, Qinghong
Zhang, Zhaoting
Qian, Mingyue
Chen, Jiechun
Dong, Wanli
Li, Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Green tea is one of the most beverages with antioxidants and nutrients.
As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study.
Cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endothelial cells (HBMVECs) after oxygen-glucose deprivation/reoxygenation (OGD/R) to investigate potential anti-ischemia/reperfusion injury properties of ECG in vitro.
Markers of oxidative stress as ROS, LDH, MDA, and SOD were further assayed in our study.
Data indicated that ECG could affect neovascularization and promote cell proliferation, tube formation, and cell migration while inhibiting apoptosis and autophagy through affecting VEGF, Bcl-2, BAX, LC3B, caspase 3, mTOR, and Beclin-1 expression.
All the data suggested that ECG may be protective for the brain against ischemia/reperfusion injury by promoting neovascularization, alleviating apoptosis and autophagy, and promoting cell proliferation in HBMVECs of OGD/R.
American Psychological Association (APA)
Fu, Bing& Zeng, Qinghong& Zhang, Zhaoting& Qian, Mingyue& Chen, Jiechun& Dong, Wanli…[et al.]. 2019. Epicatechin Gallate Protects HBMVECs from IschemiaReperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205265
Modern Language Association (MLA)
Fu, Bing…[et al.]. Epicatechin Gallate Protects HBMVECs from IschemiaReperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1205265
American Medical Association (AMA)
Fu, Bing& Zeng, Qinghong& Zhang, Zhaoting& Qian, Mingyue& Chen, Jiechun& Dong, Wanli…[et al.]. Epicatechin Gallate Protects HBMVECs from IschemiaReperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1205265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205265