Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity
Joint Authors
Araujo, Layanne C. C.
de Souza, Iara Leão Luna
Ferreira, Paula Benvindo
da Conceição Correia Silva, Maria
Silva, Alexandre Sérgio
de Freitas Brito, Aline
de Souza, Alesandra Araújo
da Silva Félix, Gustavo
de Souza Sampaio, Renata
Tavares, Renata Leite
de Andrade Pereira, Reabias
Neto, Manoel Miranda
Silva, Bagnólia Araújo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The possible mechanism is involved in the effects of Spirulina platensis on vascular reactivity.
Animals were divided into sedentary group (SG) and sedentary groups supplemented with S.
platensis at doses of 50 (SG50), 150 (SG150), and 500 mg/kg (SG500).
To evaluate reactivity, cumulative concentration-response curves were constructed for phenylephrine and acetylcholine.
To evaluate the involvement of the nitric oxide (NO) pathway, aorta tissue was preincubated with L-NAME and a new curve was then obtained for phenylephrine.
Biochemical analyses were performed to evaluate nitrite levels, lipid peroxidation, and antioxidant activity.
To contractile reactivity, only SG500 (pD2=5.6±0.04 vs.
6.1±0.06, 6.2±0.02, and 6.2±0.04) showed reduction in phenylephrine contractile potency.
L-NAME caused a higher contractile response to phenylephrine in SG150 and SG500.
To relaxation, curves for SG150 (pD2=7.0±0.08 vs.
6.4±0.06) and SG500 (pD2=7.3±0.02 vs.
6.4±0.06) were shifted to the left, more so in SG500.
Nitrite was increased in SG150 and SG500.
Lipid peroxidation was reduced, and oxidation inhibition was increased in all supplemented groups, indicating enhanced antioxidant activity.
Chronic supplementation with S.
platensis (150/500 mg/kg) caused a decrease in contractile response and increase in relaxation and nitrite levels, indicating greater NO production, due to decreased oxidative stress and increased antioxidant activity.
American Psychological Association (APA)
de Freitas Brito, Aline& Silva, Alexandre Sérgio& de Souza, Alesandra Araújo& Ferreira, Paula Benvindo& de Souza, Iara Leão Luna& Araujo, Layanne C. C.…[et al.]. 2019. Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205269
Modern Language Association (MLA)
de Freitas Brito, Aline…[et al.]. Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1205269
American Medical Association (AMA)
de Freitas Brito, Aline& Silva, Alexandre Sérgio& de Souza, Alesandra Araújo& Ferreira, Paula Benvindo& de Souza, Iara Leão Luna& Araujo, Layanne C. C.…[et al.]. Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1205269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205269