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Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction
Joint Authors
Bulboacă, Adriana Elena
Bocsan, Ioana Corina
Pop, Raluca Maria
Boarescu, Paul-Mihai
Chirilă, Ioana
Gheban, Dan
Bolboacă, Sorana D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Curcumin has anti-inflammatory, antioxidative, anticarcinogenic, and cardiovascular protective effects.
Our study is aimed at evaluating the effects of pretreatment with curcumin nanoparticles (CCNP) compared to conventional curcumin (CC) on isoproterenol (ISO) induced myocardial infarction (MI) in rats.
Fifty-six Wistar-Bratislava white rats were randomly divided into eight groups of seven rats each.
Curcumin and curcumin nanoparticles were given by gavage in three different doses (100 mg/kg body weight (bw), 150 mg/kg bw, and 200 mg/kg bw) for 15 days.
The MI was induced on day 13 using 100 mg/kg bw ISO administered twice, with the second dose 24 h after the initial dose.
The blood samples were taken 24 h after the last dose of ISO.
The antioxidant, anti-inflammatory, and cardioprotective effects were evaluated in all groups.
All doses of CC and CCNP offered a cardioprotective effect by preventing creatine kinase-MB leakage from cardiomyocytes, with the best result for CCNP.
All the oxidative stress parameters were significantly improved after CCNP compared to CC pretreatment.
CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels (such as TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES) after MI.
MMP-2 and MMP-9 levels decreased more after pretreatment with CCNP than with CC.
CCNP better prevented myocardial necrosis and reduced interstitial edema and neutrophil infiltration than CC, on histopathological examination.
Therefore, improving the bioactivity of curcumin by nanotechnology may help limit cardiac injury after myocardial infarction.
American Psychological Association (APA)
Boarescu, Paul-Mihai& Chirilă, Ioana& Bulboacă, Adriana Elena& Bocsan, Ioana Corina& Pop, Raluca Maria& Gheban, Dan…[et al.]. 2019. Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205276
Modern Language Association (MLA)
Boarescu, Paul-Mihai…[et al.]. Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1205276
American Medical Association (AMA)
Boarescu, Paul-Mihai& Chirilă, Ioana& Bulboacă, Adriana Elena& Bocsan, Ioana Corina& Pop, Raluca Maria& Gheban, Dan…[et al.]. Effects of Curcumin Nanoparticles in Isoproterenol-Induced Myocardial Infarction. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1205276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205276