NOX2-Derived Reactive Oxygen Species in Cancer
Joint Authors
Grauers Wiktorin, Hanna
Aydin, Ebru
Hellstrand, Kristoffer
Martner, Anna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The formation of reactive oxygen species (ROS) by the myeloid cell NADPH oxidase NOX2 is critical for the destruction of engulfed microorganisms.
However, recent studies imply that ROS, formed by NOX2+ myeloid cells in the malignant microenvironment, exert multiple actions of relevance to the growth and spread of neoplastic cells.
By generating ROS, tumor-infiltrating myeloid cells and NOX2+ leukemic myeloid cells may thus (i) compromise the function and viability of adjacent cytotoxic lymphocytes, including natural killer (NK) cells and T cells, (ii) oxidize DNA to trigger cancer-promoting somatic mutations, and (iii) affect the redox balance in cancer cells to control their proliferation and survival.
Here, we discuss the impact of NOX2-derived ROS for tumorigenesis, tumor progression, regulation of antitumor immunity, and metastasis.
We propose that NOX2 may be a targetable immune checkpoint in cancer.
American Psychological Association (APA)
Grauers Wiktorin, Hanna& Aydin, Ebru& Hellstrand, Kristoffer& Martner, Anna. 2020. NOX2-Derived Reactive Oxygen Species in Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205285
Modern Language Association (MLA)
Grauers Wiktorin, Hanna…[et al.]. NOX2-Derived Reactive Oxygen Species in Cancer. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1205285
American Medical Association (AMA)
Grauers Wiktorin, Hanna& Aydin, Ebru& Hellstrand, Kristoffer& Martner, Anna. NOX2-Derived Reactive Oxygen Species in Cancer. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1205285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205285