Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial
Joint Authors
Starkopf, Joel
Kals, Jaak
Vähi, Mare
Eha, Jaan
Kasepalu, Teele
Kuusik, Karl
Lepner, Urmas
Zilmer, Mihkel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Aims.
Perioperative kidney injury affects 12.7% of patients undergoing lower limb revascularisation surgery.
Remote ischaemic preconditioning (RIPC) is a potentially protective procedure against organ damage and consists of short nonlethal episodes of ischaemia.
The main objective of this substudy was to evaluate the effect of RIPC on kidney function, inflammation, and oxidative stress in patients undergoing open surgical lower limb revascularisation.
Materials and Methods.
This is a subgroup analysis of a randomised, sham-controlled, double-blinded, single-centre study.
A RIPC or a sham procedure was performed noninvasively along with preparation for anaesthesia in patients undergoing open surgical lower limb revascularisation.
The RIPC protocol consisted of 4 cycles of 5 minutes of ischaemia, with 5 minutes of reperfusion between every episode.
Blood was collected for analysis preoperatively, 2, 8, and 24 hours after surgery, and urine was collected preoperatively and 24 hours after surgery.
Results.
Data of 56 patients were included in the analysis.
Serum creatinine, cystatin C, and beta-2 microglobulin increased, and eGFR decreased across all time points significantly more in the sham group than in the RIPC group (p=0.021, p=0.021, p=0.024, and p=0.015, respectively).
Comparison of two time points, baseline and 24 hours after surgery, revealed that the change in creatinine, eGFR, urea, cystatin C, and beta-2 microglobulin was significantly different between the groups (p<0.05).
Conclusions.
Our finding of reduced release of kidney injury biomarkers may indicate the renoprotective effect of RIPC in patients undergoing open surgical lower limb revascularisation.
The trial is registered with ClinicalTrials.gov NCT02689414.
American Psychological Association (APA)
Kasepalu, Teele& Kuusik, Karl& Lepner, Urmas& Starkopf, Joel& Zilmer, Mihkel& Eha, Jaan…[et al.]. 2020. Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1205287
Modern Language Association (MLA)
Kasepalu, Teele…[et al.]. Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1205287
American Medical Association (AMA)
Kasepalu, Teele& Kuusik, Karl& Lepner, Urmas& Starkopf, Joel& Zilmer, Mihkel& Eha, Jaan…[et al.]. Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1205287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205287