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In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis
Joint Authors
Silva, Adilson David da
Martins, Francislene J.
Caneschi, César A.
Senra, Mônica P.
Carvalho, Gustavo S. G.
Raposo, Nádia R. B.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Nitrogenated heterocyclic compounds are present in both natural and synthetic drugs, and hexahydropyrimidine derivatives may prove to be efficient in treating dermatomycosis causing fungi.
This study evaluated the antifungal activity of four hexahydropyrimidine derivatives against the dermatomycosis causing fungi.
These derivatives were synthesized, characterized, and assessed in terms of their activity against Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Fusarium oxysporum, and Epidermophyton floccosum between concentrations 7.8 and 1,000 μg mL−1.
Scanning electron micrographs were assessed for the active derivatives and reference drugs, and these micrographs revealed that new agents cause morphological changes in fungi.
The derivatives HHP1, HHP3, and HHP4 revealed poor activity against the four fungal strains (MICs range 500–1000 μg mL−1).
Compound HHP3 was found to be the best potential antifungal agent among those tested and was the most effective among all the active derivatives that caused morphological changes in the susceptible strains.
American Psychological Association (APA)
Martins, Francislene J.& Caneschi, César A.& Senra, Mônica P.& Carvalho, Gustavo S. G.& Silva, Adilson David da& Raposo, Nádia R. B.. 2017. In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis. The Scientific World Journal،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1205289
Modern Language Association (MLA)
Martins, Francislene J.…[et al.]. In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis. The Scientific World Journal No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1205289
American Medical Association (AMA)
Martins, Francislene J.& Caneschi, César A.& Senra, Mônica P.& Carvalho, Gustavo S. G.& Silva, Adilson David da& Raposo, Nádia R. B.. In Vitro Antifungal Activity of Hexahydropyrimidine Derivatives against the Causative Agents of Dermatomycosis. The Scientific World Journal. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1205289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205289