Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway
Joint Authors
Yang, Jing
Zhang, Jiaqi
Wang, Xue
Lei, Yan
Xiu, Cheng-Kui
Fang, Jing-Yi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-08
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Vascular endothelial senescence induced by high glucose and palmitate (HG/PA) contributes to endothelial dysfunction, which leads to diabetic cardiovascular complications.
Reduction of endothelial senescence may attenuate these pathogenic processes.
This study is aimed at determining whether Ginseng-Sanqi-Chuanxiong (GSC) extracts, traditional Chinese medicine, can ameliorate human aortic endothelial cell (HAEC) senescence under HG/PA-stressed conditions and further explore the underlying mechanism.
We found that GSC extracts significantly increased antisenescent activity by reducing the HG/PA-induced mitochondrial ROS (mtROS) levels in senescent HAECs.
GSC extracts also induced cellular mitophagy formation, which mediated the effect of GSC extracts on mtROS reduction.
Apart from this, the data showed that GSC extracts stimulated mitophagy via the AMPK pathway, and upon inhibition of AMPK by pharmacological and genetic inhibitors, GSC extract-mediated mitophagy was abolished which further led to reverse the antisenescence effect.
Taken together, these data suggest that GSC extracts prevent HG/PA-induced endothelial senescence and mtROS production by mitophagy regulation via the AMPK pathway.
Thus, the induction of mitophagy by GSC extracts may provide a novel therapeutic candidate for cardiovascular protection in metabolic syndrome.
American Psychological Association (APA)
Wang, Xue& Zhang, Jiaqi& Xiu, Cheng-Kui& Yang, Jing& Fang, Jing-Yi& Lei, Yan. 2020. Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1205301
Modern Language Association (MLA)
Wang, Xue…[et al.]. Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-22.
https://search.emarefa.net/detail/BIM-1205301
American Medical Association (AMA)
Wang, Xue& Zhang, Jiaqi& Xiu, Cheng-Kui& Yang, Jing& Fang, Jing-Yi& Lei, Yan. Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1205301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205301