Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2
Joint Authors
Tian, Yuanyuan
Song, Wei
Xu, Dongsheng
Chen, Xiao
Li, Xiaojiao
Zhao, Yuguang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Testicular dysfunction due to hyperglycemia is the main cause of infertility in diabetic men.
Over the years, in order to solve this growing problem, a lot of research has been done and a variety of treatments have been created, but so far, there is no safe, effective, and practical method to prevent male infertility caused by diabetes.
In this review, we emphasize the male infertility mechanism caused by diabetes from the effects of oxidative stress and autophagy on the function of testes via the PI3K/Akt/mTOR signaling pathway, and we highlight that oxidative stress-induced autophagy breaks the feedforward loop linking Nrf2 and p62 and promotes oxidative damage in diabetic testes.
American Psychological Association (APA)
Tian, Yuanyuan& Song, Wei& Xu, Dongsheng& Chen, Xiao& Li, Xiaojiao& Zhao, Yuguang. 2020. Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205306
Modern Language Association (MLA)
Tian, Yuanyuan…[et al.]. Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1205306
American Medical Association (AMA)
Tian, Yuanyuan& Song, Wei& Xu, Dongsheng& Chen, Xiao& Li, Xiaojiao& Zhao, Yuguang. Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205306