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Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development
Joint Authors
Eisel, Ulrich
Fischer, Roman
Pegoretti, Valentina
Swanson, Kathryn A.
Bethea, John R.
Probert, Lesley
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-12
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
CNS inflammation is a major driver of MS pathology.
Differential immune responses, including the adaptive and the innate immune system, are observed at various stages of MS and drive disease development and progression.
Next to these immune-mediated mechanisms, other mediators contribute to MS pathology.
These include immune-independent cell death of oligodendrocytes and neurons as well as oxidative stress-induced tissue damage.
In particular, the complex influence of oxidative stress on inflammation and vice versa makes therapeutic interference complex.
All approved MS therapeutics work by modulating the autoimmune response.
However, despite substantial developments in the treatment of the relapsing-remitting form of MS, approved therapies for the progressive forms of MS as well as for MS-associated concomitants are limited and much needed.
Here, we summarize the contribution of inflammation and oxidative stress to MS pathology and discuss consequences for MS therapy development.
American Psychological Association (APA)
Pegoretti, Valentina& Swanson, Kathryn A.& Bethea, John R.& Probert, Lesley& Eisel, Ulrich& Fischer, Roman. 2020. Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205316
Modern Language Association (MLA)
Pegoretti, Valentina…[et al.]. Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205316
American Medical Association (AMA)
Pegoretti, Valentina& Swanson, Kathryn A.& Bethea, John R.& Probert, Lesley& Eisel, Ulrich& Fischer, Roman. Inflammation and Oxidative Stress in Multiple Sclerosis: Consequences for Therapy Development. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205316