Protective Role of mTOR in Liver IschemiaReperfusion Injury: Involvement of Inflammation and Autophagy
Joint Authors
Li, Huili
Wang, Jiliang
Guo, Jianrong
Gu, Jian
Chen, Ke
Zhang, Tao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Liver ischemia/reperfusion (IR) injury is a common phenomenon after liver resection and transplantation, which often results in liver graft dysfunction such as delayed graft function and primary nonfunction.
The mammalian target of rapamycin (mTOR) is an evolutionarily highly conserved serine/threonine protein kinase, which coordinates cell growth and metabolism through sensing environmental inputs under physiological or pathological conditions, involved in the pathophysiological process of IR injury.
In this review, we mainly present current evidence of the beneficial role of mTOR in modulating inflammation and autophagy under liver IR to provide some evidence for the potential therapies for liver IR injury.
American Psychological Association (APA)
Zhang, Tao& Guo, Jianrong& Gu, Jian& Chen, Ke& Li, Huili& Wang, Jiliang. 2019. Protective Role of mTOR in Liver IschemiaReperfusion Injury: Involvement of Inflammation and Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205322
Modern Language Association (MLA)
Zhang, Tao…[et al.]. Protective Role of mTOR in Liver IschemiaReperfusion Injury: Involvement of Inflammation and Autophagy. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-17.
https://search.emarefa.net/detail/BIM-1205322
American Medical Association (AMA)
Zhang, Tao& Guo, Jianrong& Gu, Jian& Chen, Ke& Li, Huili& Wang, Jiliang. Protective Role of mTOR in Liver IschemiaReperfusion Injury: Involvement of Inflammation and Autophagy. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-17.
https://search.emarefa.net/detail/BIM-1205322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205322