Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets—From Bench to Bed Site
Joint Authors
Szahidewicz-Krupska, E.
Doroszko, A.
Gawrys, Jakub
Gajecki, Damian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Pulmonary hypertension (PH) is defined as increased mean pulmonary artery pressure (mPAP) above 25 mmHg, measured at rest by right heart catheterization.
The exact global prevalence of PH is difficult to estimate, mainly due to the complex aetiology, and its spread may be underestimated.
To date, numerous studies on the aetiology and pathophysiology of PH at molecular level were conducted.
Simultaneously, some clinical studies have shown potential usefulness of well-known and widely recognized cardiovascular biomarkers, but their potential clinical usefulness in diagnosis and management of PH is poor due to their low specificity accompanied with numerous other cardiovascular comorbidities of PH subjects.
On the other hand, a large body of basic research-based studies provides us with novel molecular pathomechanisms, biomarkers, and drug targets, according to the evidence-based medicine principles.
Unfortunately, the simple implementation of these results to clinical practice is impossible due to a large heterogeneity of the PH pathophysiology, where the clinical symptoms constitute only a common denominator and a final result of numerous crosstalking metabolic pathways.
Therefore, future studies, based mostly on translational medicine, are needed in order to both organize better the pathophysiological classification of various forms of PH and define precisely the optimal diagnostic markers and therapeutic targets in particular forms of PH.
This review paper summarizes the current state of the art regarding the molecular background of PH with respect to its current classification.
Novel therapeutic strategies and potential biomarkers are discussed with respect to their limitations in use in common clinical practice.
American Psychological Association (APA)
Gajecki, Damian& Gawrys, Jakub& Szahidewicz-Krupska, E.& Doroszko, A.. 2020. Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets—From Bench to Bed Site. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205323
Modern Language Association (MLA)
Gajecki, Damian…[et al.]. Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets—From Bench to Bed Site. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1205323
American Medical Association (AMA)
Gajecki, Damian& Gawrys, Jakub& Szahidewicz-Krupska, E.& Doroszko, A.. Novel Molecular Mechanisms of Pulmonary Hypertension: A Search for Biomarkers and Novel Drug Targets—From Bench to Bed Site. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205323