SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts
Joint Authors
Lu, Bo
Christensen, Ian T.
Yu, Tao
Wang, Chunxia
Yan, Qichang
Wang, Xinling
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Oxidative stress plays an important role in the pathogenesis of cataracts.
Small ubiquitin-like modifier (SUMO) proteins have great effects on cell stress response.
Previous studies have shown that TP53INP1 can arrest cell growth and induce apoptosis by modulating p53 transcriptional activity and that both TP53INP1 and p53 are substrates of SUMOylation.
However, no previous research has studied the effect of SUMOylation on the oxidative stress response in cataracts.
This is the first study to investigate the effect of SUMOylation of TP53INP1 in oxidative stress-induced lens epithelial cell injury and age-related cataract formation.
We found that the oxidative stress-induced endogenous SUMOylation of TP53INP1 promoted human lens epithelial cell (holed) apoptosis and regulated hLEC antioxidant effects by increasing the stability and transcription of TP53INP1 in age-related cataracts.
SUMO-1, SUMOylation, and TP53INP1 were upregulated in lens tissues affected by age-related cataracts.
A SUMO-1-specific protease, SENP1, acted as an oxidative stress-sensitive target gene in hLECs.
This study identified for the first time that TP53INP1 can be SUMOylated in vivo, that the SUMOylation of TP53INP1 is induced by oxidative stress, and that SUMOylation/deSUMOylation can affect the stability and transcription of TP53INP1 in hLECs.
American Psychological Association (APA)
Lu, Bo& Christensen, Ian T.& Yu, Tao& Wang, Chunxia& Yan, Qichang& Wang, Xinling. 2019. SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205333
Modern Language Association (MLA)
Lu, Bo…[et al.]. SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1205333
American Medical Association (AMA)
Lu, Bo& Christensen, Ian T.& Yu, Tao& Wang, Chunxia& Yan, Qichang& Wang, Xinling. SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1205333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205333