Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats
Joint Authors
Souza, Grasielly Rocha
Duarte, Gloria Pinto
Rolim, Larissa Araújo
Júnior, Ivanildo I. da S.
Barbosa, Humberto de Moura
Carvalho, Débora C. R.
Barros, Ruideglan de Alencar
Albuquerque, Flávia Peixoto
da Silva, Dionísio Henrique Amaral
Souza, Nathália A. C.
Silva, Flaviane M. M.
Oliveira Júnior, Flávio Monteiro de
Gomes, Dayane A.
Lira, Eduardo C.
Almeida, Jackson Roberto Guedes da Silva
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Morus nigra has been used popularly for several proposes, including diabetic.
In an attempt to support medicinal value, the acute hypoglycemic, hypolipidemic, and antioxidant effects of the ethanolic extract of Morus nigra (EEMn 200 or 400 mg/kg b.w.) were evaluated in normal and alloxan-induced diabetic treated for 14 days.
Serum biochemical and antioxidant analysis were performed at the end of experiment.
Oral glucose tolerance test was performed at 10th and 15th days.
Chromatographic analysis by HPLC-DAD of EEMn was performed.
Insulin was used as positive control to glycemic metabolism as well as fenofibrate to lipid metabolism.
EEMn (400 mg/kg/day) reduced fasting and postprandial glycaemia, improved oral glucose tolerance, and reduced lipolysis and proteolysis in diabetic rats.
EEMn decreased the blood levels of total cholesterol and increased HDL level when compared to the diabetic control rats.
At higher levels, EEMn reduced triglycerides and VLDL levels in diabetic rats.
Also, EEMn reduced malondialdehyde and increased the reduced glutathione levels in liver of diabetic rats.
Chromatographic analysis identified the presence of the flavonoids rutin, isoquercetin, and kaempferitrin.
Acute EEMn treatment reduced hyperglycemia, improved oral glucose tolerance, and minimized dyslipidemia and oxidative stress leading to a reduction in atherogenic index in alloxan-induced diabetic rats.
American Psychological Association (APA)
Júnior, Ivanildo I. da S.& Barbosa, Humberto de Moura& Carvalho, Débora C. R.& Barros, Ruideglan de Alencar& Albuquerque, Flávia Peixoto& da Silva, Dionísio Henrique Amaral…[et al.]. 2017. Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats. The Scientific World Journal،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1205375
Modern Language Association (MLA)
Júnior, Ivanildo I. da S.…[et al.]. Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats. The Scientific World Journal No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1205375
American Medical Association (AMA)
Júnior, Ivanildo I. da S.& Barbosa, Humberto de Moura& Carvalho, Débora C. R.& Barros, Ruideglan de Alencar& Albuquerque, Flávia Peixoto& da Silva, Dionísio Henrique Amaral…[et al.]. Brazilian Morus nigra Attenuated Hyperglycemia, Dyslipidemia, and Prooxidant Status in Alloxan-Induced Diabetic Rats. The Scientific World Journal. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1205375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205375