Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation
Joint Authors
Skrzypek, Michał
Romuk, Ewa
Gąsior, Mariusz
Szczurek, Wioletta
Zembala, Michał
Szyguła-Jurkiewicz, Bożena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is defined as an imbalance between the production of free radicals and their elimination by the antioxidant defense system.
However, the role of oxidative stress in cardiac allograft vasculopathy (CAV) has not been fully understood.
Therefore, this study is aimed at determining the role of oxidative-antioxidative balance disturbances in patients after HT.
Furthermore, we sought to analyze factors associated with the presence of CAV, with particular emphasis placed on oxidative stress markers.
The study analyzed data of 194 consecutive patients after HT who underwent routine visits in the Transplantation Clinic between 2015 and 2016.
Total oxidant status (TOS) and total antioxidant capacity (TAC) were measured by the method described by Erel.
The oxidative stress index (OSI) was defined as the ratio of the TOS to TAC levels.
Patients’ mean age was 55.4±15.0 years, and 73.4% were men.
The frequency of CAV was 50%.
The area under the receiver operating characteristic curves indicated a good discriminatory power of TAC and TOS (0.8940 (0.8515-0.9365); 0.8620 (0.8126-0.9114), respectively) as well as excellent discriminatory power of OSI (0.9530 (0.9279-0.9781)) for CAV detection.
Multivariate analysis of the Cox proportional hazard model confirmed that OSI (hazard ratio HR=1.294 (1.204-1.391), p<0.0001), age (HR=1.023 (1.006-1.041), p=0.0091), and high-sensitivity C-reactive protein (HR=1.049 (1.016-1.083), p=0.0151) were independently associated with CAV presence.
In conclusion, TAC and TOS had a good discriminatory power and OSI had excellent strength for detecting CAV.
The independent factors of CAV were higher OSI and CRP levels, as well as older recipient age.
American Psychological Association (APA)
Szczurek, Wioletta& Gąsior, Mariusz& Romuk, Ewa& Skrzypek, Michał& Zembala, Michał& Szyguła-Jurkiewicz, Bożena. 2020. Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205376
Modern Language Association (MLA)
Szczurek, Wioletta…[et al.]. Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1205376
American Medical Association (AMA)
Szczurek, Wioletta& Gąsior, Mariusz& Romuk, Ewa& Skrzypek, Michał& Zembala, Michał& Szyguła-Jurkiewicz, Bożena. Investigation of the Role of Oxidative Stress and Factors Associated with Cardiac Allograft Vasculopathy in Patients after Heart Transplantation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205376