Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model
Joint Authors
Zheng, Yijun
Zhu, Duming
Zhang, Jincheng
Wang, Yang
Ju, Minjie
Song, Jieqiong
Lin, Shilong
Wen, Lu
Zhong, Ming
Pan, Shuming
Yang, Guangtian
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cardiac arrest (CA) yields poor neurological outcomes.
Salubrinal (Sal), an endoplasmic reticulum (ER) stress inhibitor, has been shown to have neuroprotective effects in both in vivo and in vitro brain injury models.
This study investigated the neuroprotective mechanisms of Sal in postresuscitation brain damage in a rodent model of CA.
In the present study, rats were subjected to 6 min of CA and then successfully resuscitated.
Either Sal (1 mg/kg) or vehicle (DMSO) was injected blindly 30 min before the induction of CA.
Neurological status was assessed 24 h after CA, and the cortex was collected for analysis.
As a result, we observed that, compared with the vehicle-treated animals, the rats pretreated with Sal exhibited markedly improved neurological performance and cortical mitochondrial morphology 24 h after CA.
Moreover, Sal pretreatment was associated with the following: (1) upregulation of superoxide dismutase activity and a reduction in maleic dialdehyde content; (2) preserved mitochondrial membrane potential; (3) amelioration of the abnormal distribution of cytochrome C; and (4) an increased Bcl-2/Bax ratio, decreased cleaved caspase 3 upregulation, and enhanced HIF-1α expression.
Our findings suggested that Sal treatment improved neurological dysfunction 24 h after CPR (cardiopulmonary resuscitation), possibly through mitochondrial preservation and stabilizing the structure of HIF-1α.
American Psychological Association (APA)
Zhang, Jincheng& Wang, Yang& Ju, Minjie& Song, Jieqiong& Zheng, Yijun& Lin, Shilong…[et al.]. 2020. Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205380
Modern Language Association (MLA)
Zhang, Jincheng…[et al.]. Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1205380
American Medical Association (AMA)
Zhang, Jincheng& Wang, Yang& Ju, Minjie& Song, Jieqiong& Zheng, Yijun& Lin, Shilong…[et al.]. Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1205380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205380