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Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways
Joint Authors
Zheng, Xiaodong
Yu, Xin
Jia, Ruoyi
Wang, Yaxuan
Chen, Wen
Chu, Qiang
Li, Yonglu
Hua, Zheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glutamic acid (Glu) is a worldwide flavor enhancer with various positive effects.
However, Glu-induced neurotoxicity has been reported less.
Tetrastigma hemsleyanum (TH), a rare herbal plant in China, possesses high medicinal value.
More studies paid attention to tuber of TH whereas vine part (THV) attracts fewer focus.
In this study, we extracted and purified flavones from THV (THVF), and UPLC-TOF/MS showed THVF was consisted of 3-caffeoylquinic acid, 5-caffeoylquinic acid, quercetin-3-O-rutinoside, and kaempferol-3-O-rutinoside.
In vitro, Glu caused severe cytotoxicity, genotoxicity, mitochondrial dysfunction, and oxidative damage to rat phaeochromocytoma (PC12) cells.
Conversely, THVF attenuated Glu-induced toxicity via MAPK pathways.
In vivo, the neurotoxicity triggered by Glu restrained the athletic ability in Caenorhabditis elegans (C.
elegans).
The treatment of THVF reversed the situation induced by Glu.
In a word, Glu could cause neurotoxicity and THVF owns potential neuroprotective effects both in vitro and in vivo via MAPK pathways.
American Psychological Association (APA)
Chu, Qiang& Li, Yonglu& Hua, Zheng& Wang, Yaxuan& Yu, Xin& Jia, Ruoyi…[et al.]. 2020. Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205385
Modern Language Association (MLA)
Chu, Qiang…[et al.]. Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205385
American Medical Association (AMA)
Chu, Qiang& Li, Yonglu& Hua, Zheng& Wang, Yaxuan& Yu, Xin& Jia, Ruoyi…[et al.]. Tetrastigma hemsleyanum Vine Flavone Ameliorates Glutamic Acid-Induced Neurotoxicity via MAPK Pathways. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205385