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Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)
Joint Authors
Hirota, Beatriz Cristina Konopatzki
Paula, Cristiane da Silva
Oliveira, Vinícius Bednarczuk de
Miguel, Obdulio Gomes
Miguel, Marilis Dallarmi
Koolen, Hector Henrique Ferreira
Verdam, Maria Christina dos Santos
Guilhon-Simplicio, Fernanda
Andrade, Kleyton Cardoso de
Fernandes, Karina Lorena Meira
Machado, Tallita Marques
da Silva, Felipe Moura Araújo
Souza, Mayane Pereira de
Miyazaki, Cristina Mayumi Sasaki
Kalegari, Milena
Stuelp-Campelo, Patricia Maria
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Background.
Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties.
Nevertheless, Byrsonima duckeana W.
R.
Anderson is an Amazonian species almost not studied.
Objective.
To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves.
Materials and Methods.
We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays.
Results.
All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests.
We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples.
B.
duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%.
In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples.
FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity.
Conclusion.
B.
duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.
American Psychological Association (APA)
Verdam, Maria Christina dos Santos& Guilhon-Simplicio, Fernanda& Andrade, Kleyton Cardoso de& Fernandes, Karina Lorena Meira& Machado, Tallita Marques& da Silva, Felipe Moura Araújo…[et al.]. 2017. Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae). The Scientific World Journal،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1205413
Modern Language Association (MLA)
Verdam, Maria Christina dos Santos…[et al.]. Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae). The Scientific World Journal No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1205413
American Medical Association (AMA)
Verdam, Maria Christina dos Santos& Guilhon-Simplicio, Fernanda& Andrade, Kleyton Cardoso de& Fernandes, Karina Lorena Meira& Machado, Tallita Marques& da Silva, Felipe Moura Araújo…[et al.]. Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae). The Scientific World Journal. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1205413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205413