A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms
Joint Authors
Chen, Liang
Kan, Juntao
Zhang, Xue
Du, Jun
Cheng, Junrui
Guo, Jun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prevalence of light-induced eye fatigue is increasing globally.
Efficient regimen for mitigating light-induced retinal damage is becoming a compelling need for modern society.
We investigated the effects of a novel combination of lutein ester, zeaxanthin, chrysanthemum, goji berry, and black currant extracts against retinal damage.
In the current work, both in vitro and in vivo light-induced retinal damage models were employed.
Animal study showed that under strong light exposure (15000 lx for 2 hours), the a-wave and b-wave from electroretinogram were significantly decreased.
Treatment with the combination significantly restored the decrease for b-wave under high- and low-stimulus intensity.
Histological analysis reported a substantial decrease in the outer nuclear layer (ONL) thickness in the model group, while the supplementation with the combination significantly improved the ONL thickness.
To further explore the underlying mechanism of the protective effects, we utilized ARPE-19 retinal pigment epithelial cell line and found that strong light stimulation (2900 lx for 30 minutes) significantly increased phosphorylation of p38 and JNK and decreased HIF expression.
Intriguingly, chrysanthemum, black currant extracts, lutein ester, and zeaxanthin significantly decreased the phosphorylation of p38 and JNK, while chrysanthemum, goji berry, black currant extracts, and lutein ester restored HIF expression.
The botanical combination can alleviate light-induced retina damage, potentially through antioxidant and prosurvival mechanisms.
American Psychological Association (APA)
Kan, Juntao& Cheng, Junrui& Guo, Jun& Chen, Liang& Zhang, Xue& Du, Jun. 2020. A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1205419
Modern Language Association (MLA)
Kan, Juntao…[et al.]. A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1205419
American Medical Association (AMA)
Kan, Juntao& Cheng, Junrui& Guo, Jun& Chen, Liang& Zhang, Xue& Du, Jun. A Novel Botanical Combination Attenuates Light-Induced Retinal Damage through Antioxidant and Prosurvival Mechanisms. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1205419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205419