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Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review
Joint Authors
Deli, Chariklia K.
Jamurtas, Athanasios Z.
Fatouros, Ioannis G.
Georgakouli, Kalliopi
Draganidis, Dimitrios
Papanikolaou, Konstantinos
Tsimeas, Panagiotis
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, theoretically, renders red blood cells (RBC) susceptible to oxidative stress.
G6PD deficiency has also been found in other types of cells than RBC, such as leukocytes and myocytes, where an inefficient protection against oxidative stress may occur too.
Glutathione (GSH), a significant antioxidant molecule, levels are lower in G6PD individuals, and theoretically, the probability of oxidative stress and haemolysis due to exercise in individuals with G6PD deficiency is increased, whereas dietary supplementation with antioxidants may have beneficial effects on various aspects of this enzymopathy.
Methods.
A search of the available literature was conducted using the keywords glucose-6-phosphate dehydrogenase (G6PD), deficiency, disease, exercise, muscle, antioxidant, vitamin, supplement, and supplementation.
The search was limited to publications in English, conducted on humans, and published until August 2018.
After screening, only relevant articles were included.
Results.
There is little evidence indicating that G6PD deficiency can cause perturbations in redox status, haemolysis, and clinical symptoms such as fatigability and myoglobinuria, especially after intense exercise, compared to individuals with normal enzyme levels.
Conclusions.
Exercise could be used by G6PD-deficient individuals as a tool to improve their quality of life.
However, there is a lack of training studies, and assessment of the effects of regular and systematic exercise in G6PD-deficient individuals is warranted.
Finally, since GSH levels are lower in G6PD deficiency, it would be interesting to examine the effects of antioxidant or cysteine donor supplements on redox status after exercise in these individuals.
American Psychological Association (APA)
Georgakouli, Kalliopi& Fatouros, Ioannis G.& Draganidis, Dimitrios& Papanikolaou, Konstantinos& Tsimeas, Panagiotis& Deli, Chariklia K.…[et al.]. 2019. Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205426
Modern Language Association (MLA)
Georgakouli, Kalliopi…[et al.]. Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1205426
American Medical Association (AMA)
Georgakouli, Kalliopi& Fatouros, Ioannis G.& Draganidis, Dimitrios& Papanikolaou, Konstantinos& Tsimeas, Panagiotis& Deli, Chariklia K.…[et al.]. Exercise in Glucose-6-Phosphate Dehydrogenase Deficiency: Harmful or Harmless? A Narrative Review. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1205426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205426