Spectrophotometric method for the determination of colchicine in pure and pharmaceutical forms : a kinetic study
Other Title(s)
طريقة طيفية لتقدير الكولشيسين في الصورة النقية و المنتجات الدوائية : دراسة حركية التفاعل
Joint Authors
Umar, Suad Khalifah
Abd Allah, Nur al-Din Aswaykar Yahya
Bu Jud, Fayruz Fath Allah
Rajab, Iman Muhammad Man
Source
مجلة جامعة سبها للعلوم البحتة و التطبيقية
Publisher
Publication Date
2019-12-31
Country of Publication
Libya
No. of Pages
7
Main Subjects
English Abstract
Simple, rapid spectrophotometric method for the determination of colchicine in pure as well as in dosage form is described.
This method was based on oxidation of colchicine by alkaline potassium permanganate at room temperature.
Under the optimized reaction conditions, Beer’s law correlating the absorbance with colchicine concentration was obeyed in the range of 4-20 ?gml-1.
The absorbance was measured at ?max 433, 524, and 610 nm.
The calibration graph was linear over these concentrations.
The limits of detection were 2.33, 5.83 and 2.86 µgml?¹, respectively.
The stoichiometry of the reaction was studied.
The method was successfully applied to the determination of colchicine in its pharmaceutical tablets, with high-quality accuracy and precisions.
Data Type
Conference Papers
Record ID
BIM-1205432
American Psychological Association (APA)
Umar, Suad Khalifah& Abd Allah, Nur al-Din Aswaykar Yahya& Bu Jud, Fayruz Fath Allah& Rajab, Iman Muhammad Man. 2019-12-31. Spectrophotometric method for the determination of colchicine in pure and pharmaceutical forms : a kinetic study. . Vol. 18, no. 4 (2019), pp.313-319.Sabha Murzuq : Sabha University.
https://search.emarefa.net/detail/BIM-1205432
Modern Language Association (MLA)
Umar, Suad Khalifah…[et al.]. Spectrophotometric method for the determination of colchicine in pure and pharmaceutical forms : a kinetic study. . Sabha Murzuq : Sabha University. 2019-12-31.
https://search.emarefa.net/detail/BIM-1205432
American Medical Association (AMA)
Umar, Suad Khalifah& Abd Allah, Nur al-Din Aswaykar Yahya& Bu Jud, Fayruz Fath Allah& Rajab, Iman Muhammad Man. Spectrophotometric method for the determination of colchicine in pure and pharmaceutical forms : a kinetic study. .
https://search.emarefa.net/detail/BIM-1205432