FoxC1-Induced Vascular Niche Improves Survival and Myocardial Repair of Mesenchymal Stem Cells in Infarcted Hearts
Joint Authors
Zhao, Lan
Zhang, Rui
Su, Feng
Dai, Libing
Wang, Jiahong
Cui, Jin
Huang, Weiguang
Zhang, Shaoheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-04
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Aims.
Forkhead box C1 (FoxC1) is essential for maintaining the hair follicle stem cell niche.
The role of FoxC1 in maintaining mesenchymal stem cell (MSC) niches after myocardial infarction (MI) has not been directly determined to date.
In this study, we determined to explore the possible roles and mechanisms of FoxC1 on MSC survival and function in the ischemic niche.
Methods and Results.
MI model was established in this study, and expression level of FoxC1 was overexpressed or knocked down through efficient delivery of FoxC1 transfection or siFoxC1.
Fifteen days later, the animals were allocated randomly to receive phosphate-buffered saline (PBS) injection or MSC transplantation.
We identified FoxC1 as a key regulator of maintaining the vascular niche in the infarcted hearts (IHs) by driving proangiogenic and anti-inflammatory cytokines while repressing inflammatory and fibrotic factor expression.
This vascular niche improved MSC survival and capacity in the IHs.
Importantly, FoxC1 interacted with MSCs and was required for vessel specification and differentiation of engrafted MSCs in the ischemic niches, promoting myocardial repair.
Inhibiting FoxC1 abolished these effects.
Conclusion.
These results definitively implicate FoxC1 signaling in maintaining ischemic vascular niche, which may be helpful in myocardial repair induced by MSC therapy.
American Psychological Association (APA)
Zhao, Lan& Zhang, Rui& Su, Feng& Dai, Libing& Wang, Jiahong& Cui, Jin…[et al.]. 2020. FoxC1-Induced Vascular Niche Improves Survival and Myocardial Repair of Mesenchymal Stem Cells in Infarcted Hearts. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205444
Modern Language Association (MLA)
Zhao, Lan…[et al.]. FoxC1-Induced Vascular Niche Improves Survival and Myocardial Repair of Mesenchymal Stem Cells in Infarcted Hearts. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1205444
American Medical Association (AMA)
Zhao, Lan& Zhang, Rui& Su, Feng& Dai, Libing& Wang, Jiahong& Cui, Jin…[et al.]. FoxC1-Induced Vascular Niche Improves Survival and Myocardial Repair of Mesenchymal Stem Cells in Infarcted Hearts. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1205444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205444