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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats
Joint Authors
Ereifej, Evon S.
Meade, Seth M.
Smith, Cara S.
Chen, Keying
Kleinman, Nanette
Capadona, Jeffrey R.
Source
Veterinary Medicine International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Published reports of status epilepticus due to intraperitoneal injection containing propylene glycol in rats are sparse.
In fact, there are no reports specifying a maximum safe dose of propylene glycol through intraperitoneal administration.
We report here a case of unexpected seizures in Sprague Dawley rats after receiving an intraperitoneal injection containing propylene glycol.
Nine-week-old, 225–250 gram male rats were reported to experience tremor progressing to seizures within minutes after given injections of resveratrol (30 mg/kg) dissolved in a 40 : 60 propylene glycol/corn oil vehicle solution by direct intraperitoneal (IP) slow bolus injection or via a preplaced intraperitoneal catheter.
The World Health Organization suggests a maximum dose of 25 mg/kg/day of propylene glycol taken orally and no more than 25 mg/dL in blood serum, whereas the animals used in our study got a calculated maximum 0.52 g/kg (25 times lower dose).
Blood tests from the seizing rat support a diagnosis of hemolysis and lactic acidosis which may have led to the seizures, all of which appeared to be a consequence of the propylene glycol administration.
These findings are consistent with oral and intravenous administration of propylene glycol toxicity as previously reported in other species, including humans.
To our knowledge, this report represents the first published case of status epilepticus due to an IP injection containing propylene glycol.
American Psychological Association (APA)
Ereifej, Evon S.& Meade, Seth M.& Smith, Cara S.& Chen, Keying& Kleinman, Nanette& Capadona, Jeffrey R.. 2017. Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats. Veterinary Medicine International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1205461
Modern Language Association (MLA)
Ereifej, Evon S.…[et al.]. Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats. Veterinary Medicine International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1205461
American Medical Association (AMA)
Ereifej, Evon S.& Meade, Seth M.& Smith, Cara S.& Chen, Keying& Kleinman, Nanette& Capadona, Jeffrey R.. Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats. Veterinary Medicine International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1205461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205461